Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12026594 | 0.89 | ROCK2 (0.59) | ROCK2DRD4ROCK1NPC1RAB9A | |
| SCHEMBL14441170 | 0.86 | RAB9A (0.65) | ROCK2ROCK1NPC1RAB9ACYP2C19 | |
| SCHEMBL21655002 | 0.85 | DRD4 (0.52) | ROCK2DRD4CARM1PRMT6MEN1 | |
| SCHEMBL24726480 | 0.85 | RAB9A (0.68) | ROCK2ROCK1NPC1RAB9ACYP2C19 | |
| SCHEMBL25647122 | 0.85 | RAB9A (0.68) | ROCK2ROCK1NPC1RAB9ACYP2C19 | |
| SCHEMBL27396502 | 0.85 | RAB9A (0.68) | ROCK2ROCK1NPC1RAB9ACYP2C19 | |
| SCHEMBL12089912 | 0.83 | LMNA (0.53) | ROCK2DRD4NPC1RAB9ACYP2C19 | |
| SCHEMBL21775965 | 0.83 | ROCK2 (0.51) | ROCK2DRD4ROCK1NPC1RAB9A | |
| SCHEMBL13959947 | 0.82 | NPC1 (0.72) | NPC1RAB9ACYP2C19ALDH1A1MEN1 | |
| SCHEMBL31495180 | 0.81 | KMT2A (0.66) | ROCK2DRD4NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240657-A1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240657-A1 | CHEMICAL COMPOUNDS | CCNA1, CCNT1, MKI67 | ROCK2 1853/4885DRD4 638/4885ROCK1 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.