Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.46 |
| ▸ | SPNS2 | Q8IVW8 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27913336 | 0.81 | LOXL2 (0.64) | LOXL2TAAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL1313588 | 0.80 | TSHR (0.55) | LOXL2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12351811 | 0.76 | LOXL2 (0.66) | LOXL2TAAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL6330775 | 0.75 | ATP4A (0.53) | LOXL2TAAR1RAB9AMAPTMEN1 | |
| SCHEMBL507232 | 0.72 | GAA (0.56) | RAB9AKDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL13825294 | 0.72 | LTA4H (0.67) | RAB9AKDM4EMAPTALDH1A1NPC1 | |
| SCHEMBL10087445 | 0.72 | LTA4H (0.60) | RAB9AKDM4EHTR2AMAPTALDH1A1 | |
| SCHEMBL15257249 | 0.71 | HTR2A (0.64) | TAAR1RAB9AKDM4EHTR2AMAPT | |
| SCHEMBL15257246 | 0.71 | HTR2A (0.64) | TAAR1RAB9AKDM4EHTR2AMAPT | |
| SCHEMBL394553 | 0.71 | HTR2A (0.76) | KDM4EHTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | LOXL2 1440/4885TAAR1 1905/4885HDAC3 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.