Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 8/20 | 0.51 |
| ▸ | SYK | P43405 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136145 | 0.89 | SYK (0.48) | KARS1SYKKDR | |
| SCHEMBL13136147 | 0.84 | KARS1 (0.55) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL2868383 | 0.84 | SYK (0.51) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136181 | 0.83 | SYK (0.52) | KARS1SYKKDR | |
| SCHEMBL2865910 | 0.82 | KARS1 (0.58) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136014 | 0.82 | KARS1 (0.55) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL14391061 | 0.81 | SYK (0.50) | KARS1SYKKDR | |
| SCHEMBL13136180 | 0.81 | SYK (0.47) | KARS1SYK | |
| SCHEMBL13136187 | 0.80 | SYK (0.52) | KARS1SYKKDR | |
| SCHEMBL13136179 | 0.79 | SYK (0.53) | KARS1SYKKDRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |