Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.49 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.40 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136178 | 0.83 | KARS1 (0.60) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136558 | 0.83 | KARS1 (0.58) | KARS1SYKMEN1NPC1CASP3 | |
| SCHEMBL2869029 | 0.82 | KARS1 (0.60) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL2871261 | 0.82 | KARS1 (0.50) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL2865935 | 0.81 | KARS1 (0.56) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136261 | 0.81 | KARS1 (0.62) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136328 | 0.81 | KARS1 (0.55) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136251 | 0.79 | KARS1 (0.60) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136245 | 0.79 | SYK (0.53) | KARS1SYKKDR | |
| SCHEMBL2868941 | 0.79 | KARS1 (0.53) | KARS1SYKKDRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |