Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.58 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.49 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.49 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14673768 | 0.84 | KARS1 (0.51) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136547 | 0.84 | KARS1 (0.61) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136253 | 0.83 | KARS1 (0.49) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136016 | 0.82 | KARS1 (0.62) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136620 | 0.81 | MAPT (0.45) | KARS1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL13136251 | 0.81 | KARS1 (0.60) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136549 | 0.81 | KARS1 (0.57) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136542 | 0.81 | KARS1 (0.57) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL902672 | 0.80 | KARS1 (0.74) | KARS1KCNN1KCNN2KCNN3KMT2A | |
| SCHEMBL13136613 | 0.79 | KARS1 (0.55) | KARS1KCNN1KCNN2KCNN3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |