Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312798 | 0.84 | ACKR3 (0.40) | ALDH1A1GFERMITFRAD52ACKR3 | |
| SCHEMBL1312421 | 0.77 | DRD2 (0.35) | ALDH1A1 | |
| SCHEMBL1313276 | 0.76 | ACKR3 (0.37) | ALDH1A1GFERMITFRAD52ACKR3 | |
| SCHEMBL1312314 | 0.71 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL1312800 | 0.67 | ACKR3 (0.41) | ALDH1A1GFERACKR3CHRM4 | |
| SCHEMBL2386815 | 0.65 | ALDH1A1 (0.50) | CYP1A2ALDH1A1GFERRAD52ACKR3 | |
| SCHEMBL25043765 | 0.64 | ADH1B (0.44) | CYP1A2ALDH1A1 | |
| SCHEMBL13927674 | 0.63 | ALDH1A1 (0.48) | CYP1A2ALDH1A1RAD52ACKR3HRH1 | |
| SCHEMBL5153614 | 0.62 | CYP1A2 (0.48) | ADRA2ACYP1A2ALDH1A1 | |
| SCHEMBL1489846 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292613-B1 | DIHYDROINDOLINONE DERIVATIVES | SHANGHAI INST PHARM INDUSTRY (CN) | 2015-09-30 | — | — | EP | disclosed |
| US-8829039-B2 | Dihydroindolinone derivatives | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110275671-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Indusrty (CN) | 2011-11-10 | — | — | US | disclosed |
| EP-2292613-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Industry (CN) | 2011-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275671-A1 | DIHYDROINDOLINONE DERIVATIVES | LCK, CDK5, ABL1 | ADRA2A 2603/4885CYP1A2 1632/4885ALDH1A1 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.