Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313 | 0.86 | CYP3A4 (1.00) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| SCHEMBL4437873 | 0.86 | CYP3A4 (1.00) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| Water SCHEMBL7777064 | 0.85 | CYP3A4 (0.96) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL27699078 | 0.85 | CYP3A4 (0.96) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| SCHEMBL13138666 | 0.81 | ALDH1A1 (0.59) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| SCHEMBL19748062 | 0.78 | ALDH1A1 (0.55) | TSHRCYP3A4TDP1ALDH1A1THRB | |
| SCHEMBL78293 | 0.78 | CYP3A4 (0.69) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| SCHEMBL29353815 | 0.78 | CYP3A4 (0.69) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| Aniline SCHEMBL22169148 | 0.77 | CYP3A4 (0.80) | TSHRCYP3A4TDP1ALDH1A1GAA | |
| SCHEMBL85646 | 0.76 | ALDH1A1 (1.00) | TSHRCYP3A4TDP1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | TSHR 3305/4885CYP3A4 4118/4885TDP1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.