Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049391 | 0.94 | KMT2A (0.47) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL13139542 | 0.90 | MEN1 (0.44) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL3057088 | 0.83 | MEN1 (0.53) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL13139534 | 0.79 | MEN1 (0.47) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL3055522 | 0.77 | KMT2A (0.55) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL13139533 | 0.76 | GAA (0.40) | MEN1ALDH1A1KMT2APTGER3 | |
| SCHEMBL3049389 | 0.75 | MEN1 (0.50) | MEN1ALDH1A1KMT2ASLC40A1ACLY | |
| SCHEMBL3063588 | 0.74 | HTR6 (0.51) | SLC22A12HTR6PTGDR2BRD4 | |
| SCHEMBL13139527 | 0.71 | HTR6 (0.48) | ACLYHTR6KDM4E | |
| SCHEMBL2866149 | 0.69 | KDM4E (0.41) | MEN1ALDH1A1KMT2AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | MEN1 1256/4885ALDH1A1 1551/4885KMT2A 2512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.