Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26661469 | 0.86 | JAK2 (0.50) | JAK2TYK2NR3C2RIOK2RAB9A | |
| SCHEMBL12203077 | 0.86 | MAPK14 (0.51) | JAK2TYK2NR3C2RIOK2RAB9A | |
| SCHEMBL5029364 | 0.83 | NR3C2 (0.59) | NR3C2 | |
| SCHEMBL12203086 | 0.82 | SMN1; SMN2 (0.48) | NR3C2RIOK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26722263 | 0.82 | RIOK2 (0.48) | NR3C2RIOK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2635471 | 0.81 | NR3C2 (0.47) | NR3C2RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL84506 | 0.81 | L3MBTL1 (0.52) | JAK2TYK2MAPK14L3MBTL1 | |
| SCHEMBL12203076 | 0.80 | ALDH1A1 (0.43) | NR3C2RIOK2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12062262 | 0.80 | ALDH1A1 (0.60) | RIOK2RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL12203066 | 0.78 | GCK (0.54) | NR3C2RAB9ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CCR2, CCR9, CCR1 | JAK2 105/4885TYK2 237/4885NR3C2 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.