Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146339 | 0.90 | MAPT (0.37) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL537450 | 0.85 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL537832 | 0.78 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL13145998 | 0.74 | PPARG (0.45) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL13131434 | 0.74 | PPARG (0.43) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL537640 | 0.73 | PPARG (0.42) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL30926036 | 0.67 | MAPT (0.47) | MAPTSMN1; SMN2L3MBTL1HTTNPSR1 | |
| SCHEMBL31289829 | 0.67 | TARBP2 (0.43) | MAPTSMN1; SMN2HTTNPSR1MAPK1 | |
| SCHEMBL16446548 | 0.67 | ALDH1A1 (0.46) | MAPTSMN1; SMN2HTTNPSR1MAPK1 | |
| SCHEMBL537829 | 0.67 | MAPT (0.48) | MAPTSMN1; SMN2NPSR1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114905-A1 | PERI-FUSED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |