Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13131434 | 0.93 | PPARG (0.43) | PPARGALDH1A1POLBTDP1MAPT | |
| SCHEMBL537640 | 0.93 | PPARG (0.42) | PPARGALDH1A1POLBTDP1MAPT | |
| SCHEMBL537779 | 0.82 | PPARG (0.44) | PPARGALDH1A1TDP1MAPTTP53 | |
| SCHEMBL537450 | 0.80 | MAPT (0.40) | PPARGALDH1A1POLBMAPTHPGD | |
| SCHEMBL538288 | 0.77 | THRB (0.43) | PPARGALDH1A1POLBTDP1MAPT | |
| SCHEMBL30926036 | 0.75 | MAPT (0.47) | PPARGALDH1A1TDP1MAPTHPGD | |
| SCHEMBL3532279 | 0.74 | ALDH1A1 (0.56) | ALDH1A1POLBTDP1MAPTHPGD | |
| SCHEMBL537832 | 0.74 | MAPT (0.40) | PPARGALDH1A1MAPTHPGDTP53 | |
| SCHEMBL537829 | 0.74 | MAPT (0.48) | ALDH1A1POLBTDP1MAPTHPGD | |
| SCHEMBL13145803 | 0.74 | MAPT (0.37) | ALDH1A1POLBMAPTHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114905-A1 | PERI-FUSED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |