Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13145803 | 0.90 | MAPT (0.37) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL537832 | 0.81 | MAPT (0.40) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13145998 | 0.64 | PPARG (0.45) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13131434 | 0.64 | PPARG (0.43) | MAPTALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL538215 | 0.62 | PPARG (0.41) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13675862 | 0.62 | CALM1 (0.50) | ALDH1A1L3MBTL1KDM4EKMT2A | |
| SCHEMBL20929092 | 0.61 | PPARG (0.59) | MAPTALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL28561177 | 0.61 | PPARG (0.59) | MAPTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL282501 | 0.60 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2L3MBTL1MAPK1MEN1 | |
| SCHEMBL31289771 | 0.60 | KDM4E (0.44) | MAPTLMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114905-A1 | PERI-FUSED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |