Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | PGR | P06401 | 3/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL6 | P05231 | 1/20 | 0.49 |
| ▸ | GLUL | P15104 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613937 | 1.00 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL21278181 | 1.00 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13148413 | 0.92 | HIF1A (0.58) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13102558 | 0.92 | HIF1A (0.58) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL3403972 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL3403977 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13152903 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13152830 | 0.83 | NR3C1 (0.50) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL1626382 | 0.82 | HIF1A (0.84) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL1626384 | 0.82 | HIF1A (0.84) | HIF1ALMNANR3C1HSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114476-A1 | NOVEL DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114471-A1 | NOVEL AMIDE DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |