Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | PGR | P06401 | 3/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL6 | P05231 | 1/20 | 0.49 |
| ▸ | GLUL | P15104 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148408 | 1.00 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL21278181 | 1.00 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13148413 | 0.92 | HIF1A (0.58) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13102558 | 0.92 | HIF1A (0.58) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL3403972 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL3403977 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13152903 | 0.83 | HIF1A (0.59) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL13152830 | 0.83 | NR3C1 (0.50) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL1626382 | 0.82 | HIF1A (0.84) | HIF1ALMNANR3C1HSD17B10CYP2C19 | |
| SCHEMBL1626384 | 0.82 | HIF1A (0.84) | HIF1ALMNANR3C1HSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2021-03-23 | — | — | US | disclosed |
| EP-3049089-B1 | HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RES INSTITUTE (US) | 2019-08-21 | — | — | EP | disclosed |
| US-9975918-B2 | Highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975918-B2 | Highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| WO-2018071736-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |
| US-20160251393-A1 | Highly Potent Glucocorticoids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| US-20160251393-A1 | Highly Potent Glucocorticoids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| WO-2015048316-A1 | HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251393-A1 | Highly Potent Glucocorticoids | NR3C1, NR3C2, MC2R | HIF1A 4230/4885LMNA 4563/4885NR3C1 1/4885 |
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | NR3C1, NR3C2, MC2R | HIF1A 4696/4885LMNA 4459/4885NR3C1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.