Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613937 | 0.83 | HIF1A (0.59) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL21278181 | 0.83 | HIF1A (0.59) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL13148408 | 0.83 | HIF1A (0.59) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL10062789 | 0.82 | HIF1A (0.64) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL13148413 | 0.79 | HIF1A (0.58) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL13102558 | 0.79 | HIF1A (0.58) | NR3C1HIF1ALMNAPGRCYP2C19 | |
| SCHEMBL11573398 | 0.76 | NR3C1 (0.81) | NR3C1HIF1ALMNAPGRNR1I2 | |
| SCHEMBL12396736 | 0.76 | NR3C1 (0.81) | NR3C1HIF1ALMNAPGRNR1I2 | |
| SCHEMBL3405200 | 0.76 | NR3C1 (0.62) | NR3C1HIF1ALMNAPGRCNR1 | |
| SCHEMBL3405195 | 0.76 | NR3C1 (0.62) | NR3C1HIF1ALMNAPGRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114476-A1 | NOVEL DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |