Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911620 | 0.92 | MEN1 (0.66) | MEN1KMT2ASLC6A7MGLLHSD11B1 | |
| SCHEMBL15949456 | 0.89 | MGLL (0.65) | MEN1KMT2ASLC6A7MGLLHSD11B1 | |
| SCHEMBL15949270 | 0.85 | MGLL (0.69) | MEN1KMT2ASLC6A7MGLLHSD11B1 | |
| SCHEMBL15949476 | 0.84 | HPGD (0.62) | MEN1KMT2ASLC6A7MGLLKDM4E | |
| SCHEMBL7873064 | 0.83 | MGLL (0.50) | MEN1KMT2AMGLLKDM4EALDH1A1 | |
| SCHEMBL911264 | 0.81 | HTT (0.63) | MEN1KMT2ASLC6A7MGLLKDM4E | |
| SCHEMBL911565 | 0.81 | HTT (0.63) | MEN1KMT2ASLC6A7MGLLKDM4E | |
| SCHEMBL16354227 | 0.81 | MGLL (0.57) | MEN1KMT2ASLC6A7MGLLHSD11B1 | |
| SCHEMBL912019 | 0.80 | MEN1 (0.58) | MEN1KMT2ASLC6A7MGLLKDM4E | |
| SCHEMBL2720346 | 0.79 | HSD11B1 (0.74) | MEN1KMT2ASLC6A7MGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010124112-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |