SCHEMBL7873064

SCHEMBL7873064

C=C(c1ccccc1)N1CCN(C2CN(C(=O)c3ccc(O)cc3)C2)CC1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.50
KDM4E B2RXH2 3/20 0.50
ALDH1A1 P00352 2/20 0.50
POLB P06746 1/20 0.50
L3MBTL3 Q96JM7 4/20 0.49
L3MBTL1 Q9Y468 4/20 0.49
ACACB O00763 2/20 0.46
ACACA Q13085 2/20 0.46
OPRM1 P35372 1/20 0.44
OPRD1 P41143 1/20 0.44
OPRK1 P41145 1/20 0.44
SLC18A3 Q16572 1/20 0.44
USP2 O75604 1/20 0.44
PLA2G1B P04054 1/20 0.43
ATG4B Q9Y4P1 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL694039 0.91 KDM4E (0.59) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL13148482 0.83 MEN1 (0.56) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL13148506 0.80 MGLL (0.52) MGLLALDH1A1L3MBTL3L3MBTL1ACACB
SCHEMBL15949476 0.80 HPGD (0.62) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL15949270 0.79 MGLL (0.69) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL6844784 0.79 KDM4E (0.58) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL693149 0.79 L3MBTL3 (0.59) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL6840213 0.79 KDM4E (0.58) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL694361 0.78 KDM4E (0.64) MGLLKDM4EALDH1A1POLBL3MBTL3
SCHEMBL15949260 0.76 MGLL (0.67) MGLLKDM4EALDH1A1POLBL3MBTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010124082-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124119-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124114-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124116-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124102-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124086-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124112-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed