Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | RHOC | P08134 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148954 | 0.92 | LMNA (0.47) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL628096 | 0.87 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAHTTRXRA | |
| SCHEMBL13148659 | 0.86 | RHOC (0.47) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL13148445 | 0.86 | LMNA (0.43) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL13150500 | 0.84 | LMNA (0.42) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL627651 | 0.79 | LMNA (0.59) | KDM4ESMN1; SMN2LMNAHTTRXRA | |
| SCHEMBL13150483 | 0.77 | MPL (0.51) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL628077 | 0.74 | RHOC (0.50) | KDM4ELMNAHTTALDH1A1TP53 | |
| SCHEMBL13148538 | 0.73 | KDM4E (0.45) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL13150451 | 0.73 | NOTUM (0.44) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120741-A1 | COMPOSITIONS AND METHODS FOR MODULATING RETINOL BINDING TO RETINOL BINDING PROTEIN 4 (RBP4) | IRM LLC (US) | 2010-10-21 | — | — | WO | disclosed |