Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 18/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.53 |
| ▸ | AKT1 | P31749 | 3/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.53 |
| ▸ | RPS27 | P42677 | 2/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485923 | 0.92 | MAPK8 (0.61) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1315006 | 0.92 | MAPK8 (0.61) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL2489443 | 0.92 | MAPK8 (0.54) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL13285767 | 0.90 | KDM1A (0.46) | MAPK8MAPK9MAPK1PRKD2MAPK10 | |
| SCHEMBL1314525 | 0.89 | MAPK8 (0.54) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1315675 | 0.89 | MAPK8 (0.55) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1145057 | 0.88 | MAPK8 (0.67) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1315525 | 0.88 | MAPK8 (0.53) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1314538 | 0.87 | MAPK8 (0.55) | MAPK8MAPK9CSF1RMAPK1PRKD2 | |
| SCHEMBL1314888 | 0.87 | MAPK8 (0.55) | MAPK8MAPK9CSF1RMAPK1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809538-B2 | Piperidine-containing compounds and use thereof | ARRAY BIOPHARMA INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-11-10 | — | — | US | disclosed |
| EP-2375899-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | Array Biopharma, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080864-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275608-A1 | PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF | NOS1, NOS2, ASS1 | MAPK8 3189/4885MAPK9 1568/4885CSF1R 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.