Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 6/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | SCN1A | P35498 | 2/20 | 0.55 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13149107 | 1.00 | NR2E1 (0.66) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL13149062 | 1.00 | NR2E1 (0.66) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL19442156 | 0.95 | NR2E1 (0.70) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL19442044 | 0.95 | NR2E1 (0.70) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL19440597 | 0.95 | NR2E1 (0.70) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL11122483 | 0.82 | NR2E1 (0.71) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL13149112 | 0.82 | NR2E1 (0.61) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL13149083 | 0.82 | NR2E1 (0.61) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL14070176 | 0.81 | NR2E1 (0.76) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 | |
| SCHEMBL19440598 | 0.80 | NR2E1 (1.00) | NR2E1ADRB2ADRB1CYP2D6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782488-B2 | Oligomer-beta blocker conjugates | NEKTAR THERAPEUTICS (US) | 2017-10-10 | — | — | US | disclosed |
| US-20100227865-A1 | Oligomer-Beta Blocker Conjugates | NEKTAR THERAPEUTICS | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227865-A1 | Oligomer-Beta Blocker Conjugates | ADRB1, ADRA2B, ADRB2 | NR2E1 3339/4885ADRB2 3/4885ADRB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.