Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499237 | 0.82 | ALDH1A1 (1.00) | ALDH1A1TSHRCHRM1HDAC1HDAC6 | |
| SCHEMBL6738879 | 0.81 | GSK3A (0.58) | ALDH1A1PIM1NPSR1CHRM5TDP1 | |
| SCHEMBL3723533 | 0.77 | ALDH1A1 (0.43) | ALDH1A1TSHRHDAC1HDAC6PIM1 | |
| SCHEMBL29353647 | 0.76 | TSHR (0.62) | ALDH1A1TSHRHDAC1HDAC6TP53 | |
| SCHEMBL29499523 | 0.76 | TSHR (0.62) | ALDH1A1TSHRHDAC1HDAC6TP53 | |
| SCHEMBL29261955 | 0.76 | TSHR (0.62) | ALDH1A1TSHRHDAC1HDAC6TP53 | |
| SCHEMBL7366310 | 0.76 | TSHR (0.78) | ALDH1A1TSHRNPSR1GFERKMT2A | |
| SCHEMBL30808578 | 0.76 | MEN1 (0.48) | ALDH1A1TSHRCHRM1NPSR1TP53 | |
| SCHEMBL13150765 | 0.76 | POLB (0.58) | CHRM1HDAC1HDAC6CHRM5KMT2A | |
| SCHEMBL21972320 | 0.75 | MAPT (0.74) | ALDH1A1GFERTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010116270-A1 | EP2/4 AGONISTS | PFIZER INC. (US) | 2010-10-14 | — | — | WO | disclosed |