Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | C5AR1 | P21730 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717818 | 0.82 | C5AR1 (0.48) | C5AR1KMT2ACHRM5 | |
| SCHEMBL13151666 | 0.81 | POLB (0.49) | POLBCYP1A2CYP2C9CYP2C19C5AR1 | |
| SCHEMBL13150794 | 0.78 | TSHR (0.66) | POLBMEN1KMT2ACHRM1LMNA | |
| SCHEMBL30806715 | 0.76 | POLB (0.56) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL13150780 | 0.76 | ALDH1A1 (0.70) | KMT2ACHRM1CHRM5HDAC1HDAC6 | |
| SCHEMBL30806442 | 0.74 | ATAD2 (0.52) | POLBC5AR1MEN1KMT2ACHRM1 | |
| SCHEMBL10688767 | 0.74 | POLB (1.00) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL29880432 | 0.74 | POLB (1.00) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL13150789 | 0.74 | C5AR1 (0.48) | C5AR1KMT2ACHRM5 | |
| SCHEMBL3176824 | 0.72 | PTGS1 (0.56) | POLBMEN1KMT2ACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010116270-A1 | EP2/4 AGONISTS | PFIZER INC. (US) | 2010-10-14 | — | — | WO | disclosed |