Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10098471 | 1.00 | KMT2A (0.48) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL16103418 | 1.00 | KMT2A (0.48) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL16103399 | 0.83 | ALOX15 (0.50) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL10098463 | 0.83 | ALOX15 (0.50) | KMT2AALOX15BLMPMP22DPP4 | |
| SCHEMBL944667 | 0.81 | GABRP (0.62) | KMT2ABLMPMP22DPP4DPP8 | |
| SCHEMBL21846798 | 0.81 | ALDH1A1 (0.41) | KMT2AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18576039 | 0.81 | GABRP (0.62) | KMT2ABLMPMP22DPP4DPP8 | |
| SCHEMBL15871670 | 0.81 | GABRP (0.62) | KMT2ABLMPMP22DPP4DPP8 | |
| SCHEMBL8509751 | 0.81 | GABRP (0.62) | KMT2ABLMPMP22DPP4DPP8 | |
| SCHEMBL17135504 | 0.81 | GABRP (0.62) | KMT2ABLMPMP22DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431447-A | Small molecule modulators of PCSK9 and methods of use thereof | ADAERATA LTD PARTNERSHIP | 2016-03-23 | — | — | CN | disclosed |
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | NUCHEM THERAPEUTICS (CA) | 2016-02-04 | — | — | US | disclosed |
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | NUCHEM THERAPEUTICS (CA) | 2016-02-04 | — | — | US | disclosed |
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | NUCHEM THERAPEUTICS (CA) | 2016-02-04 | — | — | US | disclosed |
| EP-2961765-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | Adaerata, Limited Partnership (CA) | 2016-01-06 | — | — | EP | disclosed |
| WO-2014139008-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | ADAERATA, LIMITED PARTNERSHIP (CA) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014139008-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | ADAERATA, LIMITED PARTNERSHIP (CA) | 2014-09-18 | — | — | WO | disclosed |
| WO-2010118309-A2 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | PCSK9, PCSK7, PCSK6 | KMT2A 1879/4885ALOX15 733/4885BLM 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.