Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 3/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152144 | 0.93 | DYRK1A (0.40) | KDM4EALDH1A1HSD17B10SGK1DYRK1A | |
| SCHEMBL13152602 | 0.92 | DYRK1A (0.43) | KDM4EALDH1A1HSD17B10SGK1DYRK1A | |
| SCHEMBL13152229 | 0.90 | GRIK2 (0.43) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152362 | 0.90 | GRIK2 (0.43) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152664 | 0.90 | SGK1 (0.37) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152731 | 0.90 | ALOX15 (0.36) | KDM4EALDH1A1MAPK1SGK1DYRK1A | |
| SCHEMBL10253098 | 0.90 | ALDH1A1 (0.39) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10249433 | 0.89 | SGK1 (0.36) | GRIK2GRIK1SGK1DYRK1AAR | |
| SCHEMBL13152033 | 0.89 | GRIK2 (0.46) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13151781 | 0.87 | KIT (0.40) | GRIK2GRIK1KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |