Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1313021 | 0.99 | POLB (0.54) | POLBALDH1A1USP2KMT2AKDM4E | |
| SCHEMBL20236187 | 0.82 | ALDH1A1 (0.53) | ALDH1A1USP2KMT2AKDM4EESR1 | |
| SCHEMBL22217745 | 0.80 | NAMPT (0.46) | ALDH1A1USP2KMT2AKDM4EESR1 | |
| SCHEMBL1312938 | 0.80 | POLB (0.57) | POLBALDH1A1USP2KMT2AKDM4E | |
| SCHEMBL20237063 | 0.80 | ALDH1A1 (0.56) | POLBALDH1A1USP2KMT2AKDM4E | |
| SCHEMBL20236106 | 0.80 | POLB (0.50) | POLBALDH1A1USP2KMT2AKDM4E | |
| SCHEMBL12086329 | 0.77 | POLB (0.86) | POLBALDH1A1KDM4ECYP2C19LMNA | |
| SCHEMBL20237064 | 0.75 | KMT2A (0.48) | POLBALDH1A1USP2KMT2AKDM4E | |
| SCHEMBL22217691 | 0.74 | NAMPT (0.43) | ALDH1A1USP2KMT2AKDM4EESR1 | |
| SCHEMBL22217989 | 0.74 | HDAC1 (0.54) | POLBKMT2ALMNAMEN1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245183-A | New compounds v | BIOVITRUM AB PUBL | 2011-11-16 | — | — | CN | claimed |
| US-20110275637-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-11-10 | — | — | US | claimed |
| CN-102245183-A | New compounds v | BIOVITRUM AB PUBL | 2011-11-16 | — | — | CN | disclosed |
| US-20110275637-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-11-10 | — | — | US | disclosed |
| US-20110275637-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-11-10 | — | — | US | disclosed |
| US-20110275637-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275637-A1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ADIPOR2, GPR119, ADIPOR1 | POLB 3368/4885ALDH1A1 1875/4885USP2 2611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.