SCHEMBL1315751

SCHEMBL1315751

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cncc(-c2ccccc2)c1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACLY P53396 4/20 0.64
ALDH1A1 P00352 1/20 0.57
DHODH Q02127 1/20 0.56
HDAC1 Q13547 5/20 0.55
SUCNR1 Q9BXA5 1/20 0.55
HDAC2 Q92769 3/20 0.54
HDAC3 O15379 2/20 0.54
XDH P47989 3/20 0.53
SERPINE1 P05121 2/20 0.50
KAT6A Q92794 1/20 0.50
KDM4D Q6B0I6 1/20 0.50
KDM4C Q9H3R0 1/20 0.50
MEN1 O00255 1/20 0.49
MAPT P10636 1/20 0.49
PKM P14618 1/20 0.49
GRIK1 P39086 1/20 0.49
KMT2A Q03164 1/20 0.49
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12118152 0.95 ACLY (0.59) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL12118131 0.94 ACLY (0.58) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1316860 0.94 ACLY (0.58) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL12118188 0.94 HDAC1 (0.62) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1317058 0.93 HDAC1 (0.61) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1318827 0.93 ACLY (0.57) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL12118100 0.92 ACLY (0.56) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL13206083 0.92 ACLY (0.56) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1318041 0.92 ACLY (0.56) ACLYALDH1A1DHODHHDAC1SUCNR1
SCHEMBL1315560 0.92 ACLY (0.56) ACLYALDH1A1DHODHHDAC1SUCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885ALDH1A1 813/4885DHODH 2784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.