SCHEMBL1316026

SCHEMBL1316026

CC(C)(C)OC(=O)c1ccc(-c2ccccc2)cc1NC(=O)c1cc(-c2cnco2)ccc1OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ LRRK2 Q5S007 17/20 0.49
▸ PORCN Q9H237 1/20 0.40
▸ LCLAT1 Q6UWP7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316188 0.88 LRRK2 (0.52) LRRK2
SCHEMBL1316125 0.87 LRRK2 (0.61) LRRK2
SCHEMBL1316038 0.87 LRRK2 (0.61) LRRK2
SCHEMBL12117663 0.86 NPC1 (0.41) PORCNLCLAT1
SCHEMBL1318261 0.85 LRRK2 (0.45) LRRK2LCLAT1
SCHEMBL1317519 0.85 LRRK2 (0.51) LRRK2
SCHEMBL1317653 0.84 LRRK2 (0.47) LRRK2
SCHEMBL1316219 0.84 LRRK2 (0.46) LRRK2
SCHEMBL1316842 0.83 LRRK2 (0.45) LRRK2
SCHEMBL1318171 0.83 LRRK2 (0.49) LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 LRRK2 1813/4885PORCN 4336/4885LCLAT1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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