Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13125273 | 0.86 | POLB (0.54) | EPHX2SMN1; SMN2HPGDRECQLALDH1A1 | |
| SCHEMBL13621178 | 0.84 | SMN1; SMN2 (0.56) | EPHX2SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL13621182 | 0.82 | HTT (0.67) | SMN1; SMN2HPGDRECQLALDH1A1TSHR | |
| SCHEMBL1313160 | 0.81 | SMN1; SMN2 (0.56) | EPHX2SMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL13841233 | 0.79 | MEN1 (0.72) | SMN1; SMN2ALDH1A1TSHRGRIN2BMEN1 | |
| SCHEMBL1312845 | 0.79 | TP53 (0.56) | EPHX2SMN1; SMN2HPGDRECQLALDH1A1 | |
| SCHEMBL13873845 | 0.78 | EPHX2 (0.61) | EPHX2SMN1; SMN2HPGDRECQLTSHR | |
| SCHEMBL13873561 | 0.77 | EPHX2 (0.58) | EPHX2SMN1; SMN2HPGDRECQLGRIN2B | |
| SCHEMBL471106 | 0.77 | LMNA (0.57) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL13873834 | 0.76 | EPHX2 (0.58) | EPHX2SMN1; SMN2HPGDRECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267696-A1 | Amido-Thiophene Compounds and Their Use as 11-Beta-HSD1 Inhibitors | THE UNIVERSITY OF EDINBURGH | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267696-A1 | Amido-Thiophene Compounds and Their Use as 11-Beta-HSD1 Inhibitors | HSD11B1, HSD11B2, HSD17B1 | EPHX2 834/4885SMN1; SMN2 2427/4885HPGD 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.