Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KCNC1 | P48547 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245348 | 0.85 | HTR2C (0.37) | MAOAMAOBNFKB1FTONCOA1 | |
| SCHEMBL13166544 | 0.78 | NCOA1 (0.51) | MAOAMAOBNFKB1FTONCOA1 | |
| SCHEMBL13166550 | 0.72 | MAOA (0.37) | MAOAMAOBNFKB1MEN1KMT2A | |
| SCHEMBL13859943 | 0.71 | MAPT (0.58) | NCOA1MEN1KMT2AKDM4ECYP3A4 | |
| SCHEMBL13859942 | 0.66 | CLK1 (0.44) | MEN1KMT2ACYP3A4DYRK1A | |
| SCHEMBL13166549 | 0.66 | KDM4E (0.36) | NCOA1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13859944 | 0.66 | CDK5 (0.39) | NCOA1KDM4EALDH1A1CYP3A4DYRK1A | |
| SCHEMBL4429415 | 0.65 | PAX8 (0.48) | MAOAMAOBNFKB1FTOMEN1 | |
| SCHEMBL87693 | 0.65 | MAPT (0.50) | NFKB1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29463681 | 0.65 | MAPT (0.50) | NFKB1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790739-B2 | receptor tyrosine kinase MET inhibitors; anticancer agents; 8-phenyl-10H-furo[2',3':4,5]cyclohepta[1,2-b]pyridin-10-one | Merck & Co., Inc. and Merck Sharp & Dohme Corp. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7790739-B2 | receptor tyrosine kinase MET inhibitors; anticancer agents; 8-phenyl-10H-furo[2',3':4,5]cyclohepta[1,2-b]pyridin-10-one | Merck & Co., Inc. and Merck Sharp & Dohme Corp. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090247565-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-10-01 | — | — | US | disclosed |
| US-20090247565-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247565-A1 | Tyrosine Kinase Inhibitors | ABL1, ERBB2, MET | MAOA 2630/4885MAOB 2303/4885NFKB1 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.