Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185225 | 0.90 | CHEK2 (0.60) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL13167149 | 0.85 | CHEK2 (0.50) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL13185303 | 0.80 | PKN1 (0.54) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL13167125 | 0.78 | TNKS (0.38) | KCNH2 | |
| SCHEMBL20982510 | 0.75 | PKN1 (0.82) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL20550741 | 0.70 | ALOX5 (0.64) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL3341423 | 0.69 | PKN1 (0.72) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL14816640 | 0.69 | PKN1 (0.72) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL18764054 | 0.69 | CHEK2 (0.78) | CHEK2PKN1PKN2METAP2METAP1 | |
| SCHEMBL13167112 | 0.68 | PGR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249175-A1 | Dicationic compounds which selectively recognize G-quadruplex DNA | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2010-09-30 | — | — | US | disclosed |
| US-7517893-B2 | Bichalcophenes and their prodrugs as antiprotozoal agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249175-A1 | Dicationic compounds which selectively recognize G-quadruplex DNA | DDB1, DNA2, SSBP1 | CHEK2 377/4885PKN1 3159/4885PKN2 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.