Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 3/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083971 | 0.90 | HTT (0.75) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL29733373 | 0.90 | HTT (0.75) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL27924615 | 0.89 | HTT (0.73) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL4060215 | 0.86 | KMT2A (0.68) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL18715392 | 0.84 | SMN1; SMN2 (0.68) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL3550399 | 0.84 | KMT2A (0.71) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL8373059 | 0.84 | KMT2A (0.67) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL27877038 | 0.84 | KMT2A (0.68) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL16598250 | 0.84 | HTT (0.76) | HTTSMN1; SMN2KMT2AHDAC3HDAC4 | |
| SCHEMBL11818472 | 0.84 | HIF1A (0.67) | HTTSMN1; SMN2KMT2AHDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785489-B2 | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20110275631-A1 | Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275631-A1 | Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors | MMP13, MMP3, MMP11 | HTT 2843/4885SMN1; SMN2 4073/4885KMT2A 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.