Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.51 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934708 | 0.88 | KCNH2 (0.62) | KCNH2CHRNA10CHRNA9KDM4ETP53 | |
| SCHEMBL22922220 | 0.87 | KCNH2 (0.60) | KCNH2CHRNA10CHRNA9KDM4ETP53 | |
| SCHEMBL11955033 | 0.82 | KMT2A (0.51) | KCNH2KDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL14996528 | 0.82 | KCNH2 (0.51) | KCNH2CHRNA10CHRNA9KDM4ETP53 | |
| SCHEMBL13168435 | 0.79 | DRD2 (0.54) | KDM4ETP53CYP2D6CYP3A4CYP1A2 | |
| SCHEMBL5356200 | 0.79 | KDM4E (0.62) | KCNH2CHRNA10CHRNA9KDM4ETP53 | |
| SCHEMBL12944876 | 0.79 | CYP2C9 (0.52) | CYP2D6CYP3A4CYP1A2TSHRCYP2C9 | |
| SCHEMBL11955829 | 0.78 | CA12 (0.43) | KCNH2KDM4ECYP2D6CYP3A4CYP1A2 | |
| SCHEMBL13131049 | 0.78 | KDM4E (0.46) | KCNH2CHRNA10CHRNA9KDM4ETP53 | |
| SCHEMBL250799 | 0.76 | KDM4E (0.58) | KCNH2CHRNA10CHRNA9KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | KCNH2 257/4885CHRNA10 1634/4885CHRNA9 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.