Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | OGA | O60502 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996495 | 0.84 | AR (0.43) | ARPARP1TSHRCYP3A4HIF1A | |
| SCHEMBL13168224 | 0.82 | OGA (0.46) | TSHRCYP2D6CYP1A2OGACYP2C9 | |
| SCHEMBL11947863 | 0.81 | AR (0.41) | ARPARP1TSHRCYP3A4HIF1A | |
| SCHEMBL30328006 | 0.78 | CYP2D6 (0.51) | ARPARP1TSHRCYP3A4HIF1A | |
| SCHEMBL12944876 | 0.77 | CYP2C9 (0.52) | TSHRCYP3A4HIF1ACYP2D6CYP1A2 | |
| SCHEMBL484906 | 0.77 | CYP3A4 (0.50) | PARP1TSHRCYP3A4HIF1ACYP2D6 | |
| SCHEMBL11955829 | 0.77 | CA12 (0.43) | TSHRCYP3A4HIF1ACYP2D6CYP1A2 | |
| Hydrochloric Acid SCHEMBL30327806 | 0.77 | CYP2D6 (0.50) | ARPARP1TSHRCYP3A4HIF1A | |
| Hydrochloric Acid SCHEMBL30328967 | 0.76 | CYP2D6 (0.49) | ARPARP1TSHRCYP3A4HIF1A | |
| SCHEMBL13168259 | 0.76 | HRH3 (0.40) | NPY2RTSHRCYP3A4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | AR 219/4885PARP1 1255/4885SYK 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.