Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11035315 | 0.89 | KDM4E (0.35) | MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL588750 | 0.79 | NPC1 (0.35) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL30712008 | 0.64 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL2922186 | 0.63 | KDM4E (0.53) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL1617798 | 0.63 | KDM4E (0.59) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9386510 | 0.62 | — | — | |
| SCHEMBL11111028 | 0.62 | APOBEC3A (0.32) | ALDH1A1 | |
| SCHEMBL24954180 | 0.61 | KDM4E (0.57) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL23586251 | 0.61 | PDE10A (0.38) | — | |
| SCHEMBL3799303 | 0.60 | PDE4B (0.33) | MAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215093-B1 | NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2011-12-14 | — | — | EP | disclosed |
| EP-1874781-B9 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2010-09-08 | — | — | EP | disclosed |
| EP-1874781-B1 | DIHYDROTHIENOPYRIMIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2009-06-24 | — | — | EP | disclosed |