Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.40 |
| ▸ | KDM6B | O15054 | 3/20 | 0.40 |
| ▸ | AOC1 | P19801 | 4/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12343952 | 0.84 | MEN1 (0.43) | KDM4CKDM6BAOC1AOC3MAP4K1 | |
| SCHEMBL20732522 | 0.80 | KDM4C (0.44) | KDM4CKDM6BAOC1AOC3PTGS1 | |
| SCHEMBL6035358 | 0.75 | CCNE2 (0.42) | KDM4CKDM6BAOC1AOC3ROCK1 | |
| SCHEMBL12018154 | 0.73 | CYP17A1 (0.48) | KDM4CKDM6BRAB9A | |
| SCHEMBL30601022 | 0.73 | CYP17A1 (0.48) | KDM4CKDM6BRAB9A | |
| SCHEMBL23889288 | 0.72 | AOC1 (0.69) | KDM4CKDM6BAOC1AOC3PTGS1 | |
| SCHEMBL15087874 | 0.71 | AOC1 (0.71) | KDM4CKDM6BAOC1AOC3PTGS1 | |
| SCHEMBL15996758 | 0.71 | CYP17A1 (0.38) | KDM4CKDM6BAOC1AOC3PTGS1 | |
| SCHEMBL17607192 | 0.70 | KCNMA1 (0.45) | KDM4C | |
| SCHEMBL10299406 | 0.69 | AOC1 (0.42) | KDM4CKDM6BAOC1AOC3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795282-B2 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2010-09-14 | — | — | US | disclosed |