Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368008 | 0.83 | RORC (0.58) | EPHX1EPHX2CYP3A4HTTPOLB | |
| SCHEMBL30876298 | 0.82 | EPHX1 (0.78) | ALDH1A1EPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL2893642 | 0.82 | EPHX1 (0.78) | ALDH1A1EPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL19049142 | 0.79 | ALDH1A1 (0.59) | ALDH1A1EPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL31453567 | 0.78 | IDO1 (0.51) | ALDH1A1EPHX1EPHX2CYP3A4MEN1 | |
| SCHEMBL27441962 | 0.78 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL13180237 | 0.78 | KMT2A (0.50) | ALDH1A1PYGLMEN1KMT2ANPC1 | |
| SCHEMBL7520700 | 0.77 | MAPT (0.45) | ALDH1A1EPHX1EPHX2CYP3A4CA2 | |
| SCHEMBL11357914 | 0.76 | ALDH1A1 (0.59) | ALDH1A1EPHX1EPHX2CA2CA4 | |
| SCHEMBL11755742 | 0.76 | SMN1; SMN2 (0.69) | ALDH1A1EPHX1EPHX2CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CCR2, CCR9, CCR1 | ALDH1A1 1572/4885EPHX1 556/4885EPHX2 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.