Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 4/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318986 | 0.85 | LMNA (0.41) | PDPK1AURKBROCK1AURKA | |
| SCHEMBL1318681 | 0.85 | LMNA (0.41) | PDPK1AURKBROCK1AURKA | |
| SCHEMBL1318984 | 0.85 | LMNA (0.41) | PDPK1AURKBROCK1AURKA | |
| SCHEMBL1317316 | 0.82 | CCNC (0.37) | CCNCCDK8EPHX2 | |
| SCHEMBL1318713 | 0.80 | AURKA (0.43) | PDPK1AURKBAURKACCNCCDK8 | |
| SCHEMBL1317034 | 0.79 | PDPK1 (0.45) | PDPK1AURKBROCK1AURKAPIK3CG | |
| SCHEMBL16966480 | 0.78 | PDPK1 (0.42) | PDPK1AURKBROCK1AURKAPIK3CG | |
| SCHEMBL1317785 | 0.77 | PDPK1 (0.42) | PDPK1AURKBROCK1AURKAPIK3CG | |
| SCHEMBL1317753 | 0.76 | PDPK1 (0.67) | PDPK1AURKBROCK1AURKAPIK3CG | |
| SCHEMBL12119506 | 0.76 | AURKA (0.51) | PDPK1AURKBROCK1AURKAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PDPK1 12/4885AURKB 262/4885ROCK1 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.