Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14044152 | 0.85 | HSP90AA1 (0.51) | HSP90AA1LRRK2ALDH1A1KMT2A | |
| SCHEMBL19657117 | 0.83 | ALDH1A1 (0.58) | HSP90AA1HSP90AB1POLBHTTLRRK2 | |
| SCHEMBL16200383 | 0.81 | POLB (0.54) | HSP90AA1POLBHTTLRRK2GAA | |
| SCHEMBL21958460 | 0.78 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1LRRK2GAAKDM4E | |
| SCHEMBL15650406 | 0.77 | KDM4E (0.57) | HSP90AA1HTTLRRK2GAAKDM4E | |
| SCHEMBL13066185 | 0.75 | HPGD (0.45) | POLBHTTGAAKDM4EALDH1A1 | |
| SCHEMBL13184310 | 0.75 | ALDH1A1 (0.44) | HTTGAAKDM4EALDH1A1MAPT | |
| SCHEMBL11976993 | 0.74 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1GAAALDH1A1MAPT | |
| SCHEMBL5079739 | 0.74 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HTTGAAKDM4E | |
| SCHEMBL18929812 | 0.74 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1LRRK2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240618-A1 | SUBSTITUTED PIPERAZINES | CCR1, CCR3, CCRL2 | HSP90AA1 1178/4885HSP90AB1 1526/4885POLB 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.