Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184376 | 0.85 | HSP90AA1 (0.54) | HSP90AA1LRRK2KMT2AALDH1A1 | |
| SCHEMBL16200405 | 0.81 | HSP90AA1 (0.52) | HSP90AA1LRRK2RXFP1PKMSUV39H2 | |
| SCHEMBL15653053 | 0.77 | HTR4 (0.61) | HSP90AA1LRRK2MEN1KMT2AHTR4 | |
| SCHEMBL13184310 | 0.75 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13066185 | 0.75 | HPGD (0.45) | MEN1KMT2AALDH1A1LCKFYN | |
| SCHEMBL14044151 | 0.74 | P2RX3 (0.45) | HSP90AA1LRRK2MEN1KMT2AALDH1A1 | |
| SCHEMBL15566861 | 0.74 | LRRK2 (0.54) | LRRK2PKMSUV39H2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9620851 | 0.73 | MEN1 (0.71) | HSP90AA1LRRK2RXFP1PKMMEN1 | |
| SCHEMBL13683195 | 0.73 | ALDH1A1 (0.48) | LRRK2MEN1KMT2AALDH1A1 | |
| SCHEMBL28191368 | 0.72 | RXFP1 (0.53) | HSP90AA1LRRK2RXFP1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |