Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13186206 | 0.88 | L3MBTL1 (0.56) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL17757708 | 0.85 | CHRM2 (0.67) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL2939739 | 0.83 | L3MBTL1 (0.64) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL11583474 | 0.82 | MAOA (0.69) | L3MBTL1CHRM2MAOAKDM4ETDP1 | |
| SCHEMBL18753925 | 0.81 | HRH4 (0.59) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL25018783 | 0.80 | HRH4 (0.75) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL21361201 | 0.80 | HRH4 (0.75) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL10875163 | 0.80 | MC4R (0.54) | HRH4HRH3L3MBTL1LMNACHRM2 | |
| SCHEMBL13166768 | 0.79 | HDAC3 (0.53) | HRH4HRH3CHRM2SMN1; SMN2KDM4E | |
| SCHEMBL14524456 | 0.79 | L3MBTL1 (0.56) | HRH4HRH3L3MBTL1LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790729-B2 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC. (CA) | 2010-09-07 | — | — | US | disclosed |