Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 6/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18137047 | 0.86 | CHRM2 (0.50) | CHRM2HRH4HRH3MAOASMN1; SMN2 | |
| SCHEMBL18753925 | 0.86 | HRH4 (0.59) | CHRM2HRH4HRH3SMN1; SMN2CYP1A2 | |
| SCHEMBL13185366 | 0.85 | HRH4 (0.53) | CHRM2HRH4HRH3MAOASMN1; SMN2 | |
| SCHEMBL11583474 | 0.83 | MAOA (0.69) | CHRM2MAOASIGMAR1L3MBTL1 | |
| SCHEMBL13985127 | 0.82 | LOXL2 (0.65) | CHRM2HRH4HRH3MAOASMN1; SMN2 | |
| SCHEMBL13166768 | 0.81 | HDAC3 (0.53) | CHRM2HRH4HRH3SMN1; SMN2 | |
| SCHEMBL14048116 | 0.79 | SCN8A (0.57) | CHRM2HRH4HRH3 | |
| SCHEMBL9259496 | 0.77 | HRH4 (0.84) | CHRM2HRH4HRH3MAOASMN1; SMN2 | |
| SCHEMBL10748421 | 0.77 | HRH4 (0.84) | CHRM2HRH4HRH3MAOASMN1; SMN2 | |
| SCHEMBL10747074 | 0.77 | HRH4 (0.84) | CHRM2HRH4HRH3MAOASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2830603-B1 | POLYAMINE TRANSPORT SELECTIVE THERAPEUTIC AGENTS WITH ENHANCED STABILITY | UNIV CENTRAL FLORIDA RES FOUND INC (US) | 2018-09-26 | — | — | EP | disclosed |
| US-9926260-B2 | Polyamine transport selective therapeutic agents with enhanced stability | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160311756-A1 | POLYAMINE TRANSPORT SELECTIVE THERAPEUTIC AGENTS WITH ENHANCED STABILITY | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-10-27 | — | — | US | disclosed |
| US-9346741-B2 | Polyamine transport selective therapeutic agents with enhanced stability | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311756-A1 | POLYAMINE TRANSPORT SELECTIVE THERAPEUTIC AGENTS WITH ENHANCED STABILITY | SLC7A1, SRM, SMS | CHRM2 4515/4885HRH4 968/4885HRH3 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.