Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | CASP1 | P29466 | 1/20 | 0.66 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | CASP7 | P55210 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428804 | 0.92 | MAPT (0.75) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL15788373 | 0.88 | ALDH1A1 (0.79) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL13186493 | 0.88 | MAPT (0.67) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL431153 | 0.87 | MAPT (1.00) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL428803 | 0.86 | ALDH1A1 (0.76) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL424896 | 0.86 | MAPT (0.83) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL429191 | 0.85 | ALDH1A1 (1.00) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL426709 | 0.85 | MAPT (0.85) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL19769239 | 0.85 | ALDH1A1 (0.73) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL14954741 | 0.85 | ALDH1A1 (0.73) | MAPTALDH1A1KMT2AKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400845-B1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECH INC (US) | 2017-02-22 | — | — | EP | disclosed |
| WO-2010099166-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2010-09-02 | — | — | WO | disclosed |