Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 12/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.70 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14954741 | 0.91 | ALDH1A1 (0.73) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL15788373 | 0.87 | ALDH1A1 (0.79) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL428803 | 0.85 | ALDH1A1 (0.76) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL30093344 | 0.85 | MAPT (0.66) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL13186294 | 0.85 | MAPT (0.77) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL430708 | 0.85 | MAPT (0.67) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL429191 | 0.85 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL428713 | 0.84 | MAPT (1.00) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL17792672 | 0.83 | SHMT2 (1.00) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL428804 | 0.83 | MAPT (0.75) | ALDH1A1CYP1A2CYP2C19MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | ALDH1A1 482/4885CYP1A2 1258/4885CYP2C19 1838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.