Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188875 | 0.92 | MKNK1 (0.55) | DEGS1HDAC6MKNK1MKNK2HDAC1 | |
| SCHEMBL13188800 | 0.90 | HDAC1 (0.55) | DEGS1HDAC6HDAC1KDM1ASMPD1 | |
| SCHEMBL13188379 | 0.90 | SMPD1 (0.53) | DEGS1HDAC6HDAC1KDM1ASMPD1 | |
| SCHEMBL13187914 | 0.90 | DEGS1 (0.50) | DEGS1HDAC6MKNK1MKNK2HDAC1 | |
| SCHEMBL13188871 | 0.88 | DEGS1 (0.58) | DEGS1MKNK1MKNK2LMNANPC1 | |
| SCHEMBL13188617 | 0.87 | HDAC6 (0.50) | DEGS1HDAC6MKNK1MKNK2HDAC1 | |
| SCHEMBL13187833 | 0.86 | ADORA3 (0.53) | HDAC6MKNK1MKNK2HDAC1SMPD1 | |
| SCHEMBL13187987 | 0.85 | MEN1 (0.48) | DEGS1HDAC6HDAC1KDM1ASMPD1 | |
| SCHEMBL13188018 | 0.85 | DEGS1 (0.46) | DEGS1HDAC6MKNK1MKNK2HDAC1 | |
| SCHEMBL13188322 | 0.84 | LMNA (0.53) | DEGS1HDAC6HDAC1KDM1ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |