Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188480 | 0.90 | MKNK1 (0.47) | MKNK1MKNK2LMNAHDAC1SIRT1 | |
| SCHEMBL13188490 | 0.77 | MKNK1 (0.46) | MKNK1MKNK2SMPD1 | |
| SCHEMBL19529458 | 0.71 | MKNK1 (0.47) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL28305277 | 0.70 | MKNK1 (0.71) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL1109339 | 0.69 | MKNK1 (0.73) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL606654 | 0.69 | MKNK1 (1.00) | MKNK1MKNK2SIRT1CHEK2 | |
| SCHEMBL30855339 | 0.69 | MKNK1 (1.00) | MKNK1MKNK2SIRT1CHEK2 | |
| SCHEMBL27605181 | 0.66 | MKNK1 (0.76) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL21074472 | 0.65 | MKNK1 (0.67) | MKNK1MKNK2NPC1LMNAGAA | |
| SCHEMBL21074576 | 0.65 | MKNK1 (0.67) | MKNK1MKNK2NPC1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |