Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188480 | 0.87 | MKNK1 (0.47) | MKNK1MKNK2HTTALDH1A1SMPD1 | |
| SCHEMBL13188282 | 0.83 | ABL1 (0.40) | HTTABL1BCR | |
| SCHEMBL13187830 | 0.82 | ALDH1A1 (0.46) | HTTALDH1A1KDM4EMAPT | |
| SCHEMBL13188790 | 0.82 | LMNA (0.47) | HTTALDH1A1KDM4EMAPT | |
| SCHEMBL13188370 | 0.81 | ALDH1A1 (0.45) | HTTALDH1A1KDM4EMAPT | |
| SCHEMBL13187807 | 0.77 | MKNK1 (0.50) | MKNK1MKNK2SMPD1 | |
| SCHEMBL2345607 | 0.68 | CYP19A1 (0.74) | MKNK1MKNK2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL19529458 | 0.68 | MKNK1 (0.47) | MKNK1MKNK2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL28305277 | 0.67 | MKNK1 (0.71) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL31724375 | 0.66 | ALDH1A1 (0.64) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |