Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | AKT1 | P31749 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188606 | 0.93 | CYP3A4 (0.45) | PIK3CAPIK3CGPIK3CBHDAC6MTOR | |
| SCHEMBL13188362 | 0.92 | HDAC6 (0.44) | PIK3CAPIK3CGPIK3CBHDAC6HDAC1 | |
| SCHEMBL3711558 | 0.91 | CYP3A4 (0.47) | PIK3CAPIK3CGPIK3CBHDAC6MTOR | |
| SCHEMBL3713490 | 0.91 | HDAC6 (0.45) | PIK3CAPIK3CGPIK3CBHDAC6HDAC1 | |
| SCHEMBL3710083 | 0.89 | KIT (0.42) | HDAC1CYP3A4CYP2D6CYP1A2HDAC2 | |
| SCHEMBL13187703 | 0.89 | PRKD1 (0.44) | HDAC1HDAC3HDAC2 | |
| SCHEMBL3719717 | 0.88 | MAPT (0.41) | PIK3CAPIK3CGPIK3CBHDAC6HDAC1 | |
| SCHEMBL3714505 | 0.88 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3CBMTORAKT1 | |
| SCHEMBL3714534 | 0.86 | CHEK1 (0.39) | PIK3CAPIK3CGPIK3CBHDAC6MTOR | |
| SCHEMBL3715649 | 0.86 | HIF1A (0.38) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |