Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716223 | 0.94 | ACP1 (0.56) | ACP1TSHRHDAC1HIF1AEPAS1 | |
| SCHEMBL13188495 | 0.91 | ACP1 (0.59) | ACP1TSHRHIF1AEPAS1KDM4E | |
| SCHEMBL3711837 | 0.86 | ACP1 (0.57) | ACP1TSHRHIF1AEPAS1KDM4E | |
| SCHEMBL13187973 | 0.83 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL13188420 | 0.83 | ACP1 (0.50) | ACP1TSHRHIF1AEPAS1KDM4E | |
| SCHEMBL13188494 | 0.80 | HDAC6 (0.58) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3715191 | 0.80 | ACP1 (0.57) | ACP1TSHRHDAC1HIF1AEPAS1 | |
| SCHEMBL13188424 | 0.79 | DYRK1A (0.55) | TSHRHDAC1HDAC6HDAC2HDAC8 | |
| SCHEMBL13188892 | 0.79 | HDAC6 (0.52) | HDAC1KDM4EHDAC6HDAC2HDAC8 | |
| SCHEMBL13188605 | 0.79 | HDAC6 (0.58) | HDAC1HDAC6HDAC2HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |