Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655936 | 0.86 | HDAC1 (0.54) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL2793093 | 0.85 | CYP4A11 (0.51) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL379954 | 0.84 | CYP4A11 (0.50) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL31403206 | 0.83 | TRPM8 (0.40) | HPGDHDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL24835526 | 0.82 | CYP4A11 (0.58) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL4781274 | 0.82 | HDAC3 (0.48) | ALDH1A1HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL5140738 | 0.82 | CYP4A11 (0.55) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL6018110 | 0.80 | PKM (0.45) | CYP4A11CYP4F2ALDH1A1MAPTHPGD | |
| SCHEMBL9348378 | 0.80 | NAMPT (0.44) | MAPTHDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL20236074 | 0.80 | LPAR1 (0.55) | CYP4A11CYP4F2LOXL2HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010099054-A2 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2010-09-02 | — | — | WO | disclosed |