Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 18/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | BRSK2 | Q8IWQ3 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.41 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1284631 | 0.90 | TBK1 (0.44) | TBK1KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL13432088 | 0.78 | TBK1 (0.67) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL1617905 | 0.76 | TBK1 (0.47) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL23331347 | 0.71 | TBK1 (0.50) | TBK1KDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL22818572 | 0.69 | STK17B (0.59) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL1284433 | 0.68 | STK17B (0.46) | LMNAMAPTSTK17A | |
| SCHEMBL1284430 | 0.68 | STK17B (0.46) | LMNAMAPTSTK17A | |
| SCHEMBL4182957 | 0.67 | STK17A (0.38) | KDM4EALDH1A1LMNASTK17A | |
| SCHEMBL22818574 | 0.67 | ULK1 (0.52) | TBK1IKBKECDK2MARK3BRSK2 | |
| SCHEMBL15188869 | 0.67 | TBK1 (0.50) | TBK1IKBKECDK2MARK3BRSK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |